傅磊

教授,博导|上海交通大学

概况

课题组成立于2006年初,主要从事化学药物、 药用化妆品和功能食品的研发:

1、合成具有抗糖尿病、疼痛、阿尔茨海默、肿瘤等疾病的化学分子,评估他们的生物活性;

2、承担多项省部级和横向课题研发项目,成果除在主流杂志上发表外,还获得多项国内外专利;

3、主讲多门本科生、研究生的核心课程。

Established in 2006, our group has focused its research on Pharmaceuticals, Cosmaceuticals and Nutraceuticals. We prepared chemicals and evaluated their biological activities again diabetes, chronic pain, Alzheimer's disease and cancer.

代表成果

· 在国内外相关学科的主流学术期刊上发表学术论文100余篇

· 申请中国发明专利16项(授权11项)。


教学工作

· 药物化学原理(研究生核心课程)

· 科学表达实践(研究生核心课程)

· 药物合成反应(本科生课程)

· 药物发现与开发的一般方法(本科生课程)

· 药学、化学山海经(新生研讨课)


研究领域

· 新型化学结构的有机合成方法学研究

· 化学小分子与靶向蛋白作用的质谱法研究

· 化学小分子药物的设计、合成及其生物活性评估

· 化学诱导休眠、棕色脂肪活化的机理研究


大事记

重要事件

项目

  1. 2009-11-19~2011-03-02;中草药在个人护理品中的应用研究.
  2. 新型核苷类抗病毒性肝炎药物研究.
  3. 分子探针.
  4. 上海市科委白玉兰科技人才基金.
  5. 植物提取物的功效验证.
  6. 红曲等植物提取物的质量控制及其生物功效验证.

专利

  1. 刘文陆,张健存,傅磊,彭英丹;2011年:8,8’-二-苯氨基-5,5’-二-萘基-1,1’-二-磺酸盐合成方法;专利号:ZL 2008 1 0038197.2.
  2. 傅磊,蒋玺臻,刘文陆,姜发琴,谢东升,张伟;2012年:苯并呋喃-3-甲酮取代苯基类化合物及其制备和应用;专利号:ZL 2010 1 0245092.1.
  3. 傅磊,张伟,刘文陆,姜发琴,谢东升,蒋玺臻;2012年:2-取代苯并[d]噁唑-5-丙酸化合物及其制备和应用;专利号:ZL 2001 0245093.6.
  4. 傅磊,张伟,刘文陆,姜发琴,谢东升,蒋玺臻;2013年:一类苯并[d]噁唑化合物及其制备方法;专利号:ZL 2010 1 0188642.0.
  5. 傅磊,蒋玺臻,刘文陆,姜发琴,谢东升,张伟;2014年:白藜芦醇二聚体衍生物及其制备和应用方法;专利号:ZL 2010 1 0204620.9.
  6. 傅磊,蒋玺臻,刘文陆,姜发琴,谢东升,张伟;2014年:白藜芦醇二聚体衍生物及其制备和应用方法;专利号:ZL 2013 1 0152799.1.
  7. 傅磊,刘井宝,姜发琴,蒋玺珍,刘晶晶,刘文陆;2014年:苯并呋喃类化合物及其制备方法、用途;专利号:ZL 2011 1 0242547.9.
  8. 傅磊,金焱,刘井宝,姜发琴,刘晶晶,刘文陆;2014年:红曲活性成分的提取、分离方法及用途;专利号:ZL 2011 1 0297613.2.
  9. 陈亚玲,傅磊;2012年:药物组合物;专利号:200710043629.4.
  10. 陈亚玲,傅磊,杨雪;2012年:一种外用复合油纳米乳喷雾剂和滴眼剂及其制备方法;专利号:200810037262.X.
  11. 傅磊,刘井宝,姜发琴,蒋玺臻,刘晶晶,刘文陆;2014年:3-甲基-6-取代-笨并呋喃类化合物及其制备方法和用途;专利号:ZL 2011 1 0292388.3.
  12. 傅磊,刘井宝,姜发琴,金焱,刘晶晶,刘文陆;2015年:2-取代乙烯磺酸酯类化合物及其制备方法和应用;专利号:ZL 2011 1 0287718.X.

论文

  1. A facile synthesis of novel tricyclic 4-pyridones.Xu, Buzhe; Cheng, Zhangling; Fu, lei.Tetrahedron Letters,2014.
  2. A rapid and practical catalytic esterification for the preparation of caffeic acid esters.Xie, Dongsheng; Yang, Fengzhi; Xie, Jin; Zhang, Man; Liu, Wenlu; Fu, Lei.Journal of Chemical Research,2014.
  3. Quinoxaline-2,3-diones: potential d-amino acid oxidase (DAAO) inhibitors.Xie, Dongsheng; Wang, Yanchao; Xie, Jin; Lu, Jun; Cui, Junjun; Zhang, Man; Fu, Lei; Wang, Yongxiang.Medicinal Chemistry Research,2014.
  4. [RuCl2(p-cymene)]2‑Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Ketones under Ligand-Free and Neutral Conditions.Lei Zhang, Xiaomin Xie, Lei Fu, and Zhaoguo Zhang.The Journal of organic chemistry,2013.
  5. Ru-catalyzed 1, 4-addition of arylboronic acids to acrylic acid derivatives in the presence of phenols.Zhang, Lei; Xie, Xiaomin; Peng, Zhiyong; Fu, Lei; Zhang, Zhaoguo.Chemical Communications, 40(2013)8797,2013.
  6. Palladium-Catalyzed Amidation of Aryl Halides Using 2-Dialkylphosphino-2′-alkoxyl-1,1′-binaphthyl as Ligands.Ma, FF; Xie, XM; Zhang, L; Peng, ZY; Ding, LN; Fu, L and Zhang, ZG.The Journal of Organic Chemistry,2012.
  7. Synthesis and biological evaluation of novel selenonucleosides.Chen, Y; Peng, YD; Zhang, JC; Fu, L.Nucleosides, Nucleotides and Nucleic Acids,2008.
  8. LC-MS based assay method for DPP-IV inhibitor screening and substrate discovery.Liu, JJ; Cheng, XH; Fu, L.Analytical Methods,2012.
  9. Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues.Liu, WL; Zhang, JC; Jiang, FQ; Fu, L.Arch. Pharm. Chem. Life Sci,2009.
  10. Synthesis of bis-ANS fluorescence probe in ionic liquids.Liu, WL; Jiang, FQ; Liu, JB; Zhang, JC; Fu, L;.Chinese Chemical Letters,2009.
  11. Synthesis and antimicrobial evaluation of new benzofuran derivatives.Jiang, XZ; Liu, WL; Zhang, W; Jiang, FQ; Fu L.European Journal of Medicinal Chemistry,2011.
  12. Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)- 3-(benzo[d]oxazol-5-yl)propanoic acid derivatives.Zhang, W; Liu, WL; Jiang, XZ; Jiang, FQ; Zhuang, H; Fu, L.European Journal of Medicinal Chemistry,2011.
  13. Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives.Liu, JB; Jiang, FQ; Jiang, XZ; Zhang, W; Liu, JJ; Liu, WL; Fu, L.European Journal of Medicinal Chemistry,2012.
  14. Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.Liu, JB; Jiang, FQ; Jin, Y; Zhang, Y; Liu, JJ Liu, WL; Fu, L.European Journal of Medicinal Chemistry,2012.
  15. New polyethyleneglycol-functionalized texaphyrins: Synthesis and in vitro biological studies.Wei, WH; Wang, Z; Mizuno, T; Cortez, C; Fu, L; Sirisawad, M; Naumovski, L; Magda, D; Sessler, JL.J. Chem. Soc., Dalton Transactions,2006.
  16. Functional Analogs of Cytochrome c Oxidase, Hemoglobin and Myoblobin.Collman, JP; Boulatov, R; Soundland, C; and Fu, L.Chemical Reviews,2004.
  17. Reaction chemistry of metallotexaphyrins: the synthesis and characterization of the first meso-oxotexaphlorin.Wang, Z; Fu, L and Mody, TD.Chem. Commun.,2002.
  18. Texaphyrins: Synthesis and Development of A Novel Class of Therapeutic Agents.Mody, TD; Fu, L and Sessler, J.Progress in Inorganic Chemistry,2001.
  19. A Functional Model Related to Cytochrome c Oxidase and Its Electrocatalytic Four-Electron Reduction of Dioxygen.Collman, JP; Fu, L; Herrmann, PC and Zhang, X.Science,1997.
  20. Synthetic Models for Hemoglobin and Myoglobin.Collman, J P and Fu, L.Accounts of Chemical Research,1999.
  21. A Functional Model of Cytochrome c Oxidase — Thermodynamic Implication.Collman, J P; Fu, L; Herrmann, PC; Wang, Z; Rapta, M; Broring, M.Angew. Chem.,1998.
  22. Optimisation of ultrasound-assisted extraction conditions for maximal recovery of active monacolins and removal of toxic citrinin from red yeast rice by a full factorial design coupled with response surface methodology.G.S. Zhou, L. Fu, X.B. Li.Food Chemistry, 170(2015)186-192,2015.

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