钱峰

研究员|上海交通大学

概况

实验室简要介绍

代表成果

突出研究成果

教学工作

本科生:《微生物学与免疫学》

研究生:《免疫药理学》


研究领域

(1)巨噬细胞和嗜中性粒细胞活化的分子机制与新型药物靶标。

(2)细菌感染、哮喘、肺纤维化等呼吸性疾病发病机理与分子机制。

(3)恶性肿瘤发生发展的病理分子机制与药物靶标。

(4)新型药物筛选体系建立与高通量药物筛选。


大事记

(1)巨噬细胞和嗜中性粒细胞活化的分子机制与新型药物靶标。

(2)细菌感染、哮喘、肺纤维化等呼吸性疾病发病机理与分子机制。

(3)恶性肿瘤发生发展的病理分子机制与药物靶标。

(4)新型药物筛选体系建立与高通量药物筛选。


论文

  1. Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.Hong Yin, Alesander Zakharov, Weidong Xu, Adam Corken, Alexander Zakharov, Feng Qian, Sasha Pavlovic, Alekasandar Krbanjevic, Alexander Lyubimov, Zaijie J. Wang, Xiaoping Du.Arterioscler Thromb Vasc Biol.
  2. A critical role for the guanine nucleotide exchange factor P-Rex1 in platelet secretion and aggregation.Feng Qian, Guy C. Le Breton, Jia Chen, Jing Deng, John W. Christman, Dianqing Wu, Richard D. Ye.Arterioscler Thromb Vasc Biol.
  3. MAP Kinase Phosphatase 5 protests against sepsis-induced acute lung injury.Feng Qian*, Jing Deng, Benjamin N. Gantner, Chen Dong, John W. Christman, Richard D Ye..American Journal of Physiology-Lung Cellular and Molecular Physiology.
  4. The Akt1 isoform is required for optimal IFN-b transcription through direct phosphorylation of b-catenin.Benjamin N Gantner, Huali Jin, Feng Qian, Nissim Hay, Bin He, Richard D Ye.J Immunol.
  5. Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression.Jing Deng, Xuerong Wang, Feng Qian, Stephen M. Vogel, Lei Xiao, Ravi Ranjan, Hyesuk Park, Manjula Karpurapu, Richard D. Ye, Gye Young Park, John W. Christman.J Immunol.
  6. A critical role for P-Rex1 in endothelial junction disruption and vascular hyper-permeability.Ram Naikawadi, Ni Cheng, Stephen M. Vogel, Feng Qian, Dianqing Wu, Asrar B. Malik, Richard D Ye.Circulation Research.
  7. TRPM2 regulation of membrane potential modulates NADPH oxidase-derived ROS production in phagocytes.Anke Di, Xiao-Pei Gao, Feng Qian, Takeshi Kawamura, Jin Han, Claudie Hecquet, Richard D. Ye, Stephen M. Vogel, Asrar B. Malik.Nature Immunology.
  8. Notch-1 signaling facilitates surviving expression in human non-small cell lung cancer cells.Yuqing Chen, Dianming Li, Hongli Liu, Huanbai Xu, Honghua Zheng, Feng Qian, Wei Li, Chengling Zhao, Zhenhua Wang, Xiaojing Wang.Cancer Biol Ther.
  9. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.Min Ren, Qing Guo, Liang Guo, Martin Lenz, Feng Qian, Rory R. Koenen, Hua Xu, Alexander B. Schilling, Christian Weber, Richard D. Ye, Aaron R. Dinner, Wei-Jen Tang.EMBO J.
  10. A non-redundant role for MKP5 inlimiting ROS production and preventing LPS-induced vascular injury.Feng Qian, Jing Deng, Ni Cheng, Emily J. Welch, Yongliang Zhang, Asrar B. Malik, Richard A. Flavell, Chen Dong, Richard D. Ye.EMBO J.
  11. Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo.Ran Song, Feng Qian, Yu-Pei Li, Xia Sheng, Shao-Xian Cao, Qiang Xu.PLoS ONE.
  12. PRL-3 siRNA inhibits the metastasis of B16-BL6 mouse melanoma cells in vitro and in vivo.Feng Qian, Yu-Pei Li, Xia Sheng, Zi-Chao Zhang, Ran Song, Wei Dong, Shao-Xian Cao, Zi-Chun Hua, Qiang Xu.Mol. Med.
  13. Identification of a new metabolite of Astilbin,3’-O-Methylastilbin, and its immunosuppressive activity against contact dermatitis.Jianming Guo, Feng Qian, Jianxin Li, Qiang Xu, Ting Chen.Chinical Chemistry.
  14. Nitric oxide inhibits T cell adhesion and migration through down-regulating β1 integrin expression in immunological liver injured mice.Yang Sun, Jianli Liu, Feng Qian, Qiang Xu.Intl. Immunopharmacol.
  15. Interaction between integrin α5 and fibronectin is required for metastasis of B16F10 melanoma cells.Feng Qian, Zi-Chao Zhang, Xue-Feng Wu, Yu-Pei Li, Qiang Xu.Biochem. Biophys. Res. Commun.

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